Jose Andres Barrientos-Retinopathy of Prematurity-(Argentina)

Name: Jose Andres Barrientos
Sex: Male
Nationality: Argentinean
Age: 29Y
Diagnosis: Retinopathy of Prematurity
Discharge Date: 2019/08/02

Before treatment:
The patient was born by caesarean section at 28 weeks of gestation. He weighed 800g and was discharged after 2 months in the incubator. No abnormality was found during that period. Four months later his parents found he had  visual impairment. He was taken to the local hospital and diagnosed as having" Retinopathy of Prematurity." There was no treatment method. At present the patient has no vision and no sense of light in both eyes.
His spirit is good, diet and sleep are basically normal and the urination and defecation functions are normal.

Admission PE:
Bp: 117/73mmHg, pulse rate: 76/min, breathing rate 18/min, height 170cm, weight 87kg, body temperature: 36.2 degrees. The patient had good nutrition status and normal physical development. There was no bleeding spots or yellow stains of the skin or mucosa, he had a symmetrical chest, clear respiratory sounds of both lungs and no moist rales were heard. There were regular heart sounds, regular heart rhythm, no obvious murmur heard in the valves, a flat and soft abdomen without masses felt and a normal liver and spleen.

Nervous System Examination:
Patient was alert, had clear speech, normal calculation, memory and orientation abilities. His left pupil was 1mm, right pupil was 3mm. Crystalline lens were covered, there was no light reaction, normal intraocular pressure, no vision of both eyes and no reaction to light. Fundus examination: right eye: partial dull red and light yellow area was observed of the fundus, with others unobserved; left eye: cannot be seen through. He had a symmetrical forehead wrinkle and nasolabial fold, symmetrical teeth, tongue was in the middle when extended and free neck movement. There was normal muscle tone and muscle power of the 4 limbs, normal abdominal reflex and normal tendon reflexes of the 4 limbs. There was a negative sucking reflex, negative palm-jaw reflex bilaterally, negative Hoffmann sign, Rossolimo sign and Babinski sign bilaterally. Normal superficial and deep sensation, normal coordination movement and a negative meningeal irritation sign.

Treatment:
After the admission he received 3 nerve regeneration treatments (neural stem cells and mesenchymal stem cells) to repair his damaged nerves and retinal cells, replace dead nerves and cells, nourish nerves and cells, improve body environment, regulate his immune system and improve blood circulation. This was combined with rehabilitation training.   

Post-treatment:
After 14 days treatment his pupils reflected light and there was now light reflex of the pupils.

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