Andrew Cha-Spinocerebellar ataxia type 17-(United States)

Patient name: Andrew Cha
Gender: male
Age: 85 years old
Nationality: United States
Disease diagnosis: Spinocerebellar ataxia type 17

Before treatment:
The patient was admitted to the hospital as "spinocerebellar ataxia SCA17" because of progressive motor retardation, balance disorder for 3 years, aggravation with cognitive impairment, dysphagia and speech difficulty for 1 year. His main symptoms were motor retardation, balance disorder, progressive limb movement with cognitive impairment, poor comprehension, decreased memory and calculation, slow thinking, difficulty in speech expression, dysphagia, frequent cough, drooling, insomnia and sleep alternation, difficulty in urination control (wearing diapers), constipation (medication-assisted defecation). Deny other chronic diseases and infectious history.

Admission for physical examination:
The patient's blood pressure 110/78mmHg, heart rate 92 beats / min, breathing 20 beats / min. His lymph nodes were not enlarged. His skin was free from yellow stain. There was no cyanosis on his lips. He breathed clearly in both lungs and did not hear dry-wet rales. His heart sound was weak, rhythmic and free of murmur. He had soft abdomen, no tenderness and rebound pain, no enlargement of liver and spleen. There was no edema in his lower limbs.

Nervous system physical examination:
The patient sleeped more, the articulation was not clear, the comprehension was very poor, could not answer the question. He couldn't finish his memory and calculation tests. His pupils were 2mm in diameter and his light response was slow. He had poor eye movement, could not look down, had no nystagmus, and his expression was stiff and indifferent. His nose lines were symmetrical and his tongue was slowly in the middle. He had a slow pharyngeal reflex. He had dysphagia and coughed in drinking water. His left upper limb elbow joint was stiff and flexion, unable to move; his right upper limb muscle tone was increased, accompanied by tremor, muscle strength grade 4. He had increased muscle tone in both lower limbs and muscle strength of grade 3 +. His body movements were slow. He couldn't get up, stand or walk alone. The tendon reflex of his extremities was weakened. His Babinski sign was positive in both lower limbs and negative in his right foot. He felt that the examination was normal. His left finger nose test and rotation test could not be completed; his right finger nose test, finger pair test and rotation test were slow and clumsy, and the degree of completion was poor. He could not complete the calcaneus knee tibia test of both lower limbs. He couldn't stand alone. His meningeal irritation sign was negative.

Treatment process:
The patient was treated with CAST and neural stem cells plus mesenchymal stem cells to repair brain nerves, nourish nerves, improve the internal environment, immunomodulation and rehabilitation training.

After treatment:
The mental intelligence of the patient was significantly improved, his mind was clearer than that at the time of admission, he could take the initiative to communicate with others, his language was clear, his vocabulary was significantly increased, and the sentences with deeper meaning could be expressed, and the integrity of sentence expression was improved. His memory and calculation ability have improved. His motor balance function improved significantly; his facial stiffness decreased and his expression increased; his swallowing function improved, his cough decreased and his salivation disappeared. The range of movement of his left upper limb was expanded, the stiffness and retardation of his right upper limb were significantly relieved, the mobility was significantly improved, the muscle strength was increased to level 5, the finger-to-nose test of his right hand was stable, and the movement speed of the rotation test was accelerated. The stiffness of his lower limbs was gradually alleviated, his motor flexibility was improved, his muscle strength increased to grade 4 +, and the completion of the calcaneus, knee and tibia test was significantly improved. He could stand up alone from the bedside and walk dozens of meters with slight support. The tendon reflex of his extremities has basically returned to normal. The pathological index of his lower extremities decreased significantly. His cardiopulmonary function improved: his heart rate was basically maintained at 60-75 beats per minute, and his heart sound of auscultation was stronger than before.

2 weeks after treatment:
The condition of the 85-year-old Mr. Andrew Cha in the United States has been further improved. He has been able to eat independently, have daily language communication with his family, and basically regained the function of walking independently.
     

1 month after discharge:
Mr. Andrew Cha, from the United States, could not chew food before treatment, had difficulty eating, and could not stand or walk. 1 month after the treatment, he can enjoy chewing his favorite foods of McDonald's and take a leisurely walk in the garden.