Dementia
by Drs.Like Wu, Xiaojuan Wang, Bo Cheng, Susan Chu, Zoe Zhang and Xiaoling Ren
Wu Medical Center, Bejing, China
Progress in the Treatment of Dementia
Dementia is the most important and most common degenerative brain disease. Cerebral atrophy that progresses for many years, and severe brain atrophy and dementia are clinically difference from the atrophy that occurs normally with aging. The late pathologic change in patients who have dementia has been confirmed as the appearance of atrophy diffusion in the brain, and the weight of the brain is usually reduced by at least 20%. In addition, the gyrus becomes narrower and the sulci become wider. The symmetry of the third ventricle and lateral ventricle changes and they have different degrees of expansion. Microscopically, a large number of the nerve cells are lost, especially in the cerebral cortex, and the nuclei in the brain also lose nerve cells, especially in monoamine nervous system in the stem of the brain. The decrease in the number of cholinergic neurons in basal ganglia may affect memory.
The clinical manifestations of dementia include: the existence of a variety of mental disorders including personality change, inability to remember how to perform simple tasks like use household items or tools, while still retaining the ability to complete the action; inability to use a pen, razor, tableware, or unlock something. These actions are not ideational apraxia.
The most common dyspraxia are the inability to walk stably or with large steps. Towards the end of disease, certain reflexes are difficult to perform, such as grasping and sucking, and there are other signs of the frontal diseases, urinary and fecal incontinence. Patients that remain silent will eventually lose his or her ability to walk and may become paralyzed, with a complete inability to care for his- or herself.
Treatment: there is no official, effective treatment for this disease.
The Wu Stem Cell Medical Center (WSCMC) recently found that the stem cell treatment has a direct effect on dementia. The results concluded: physical performance (body paralysis) and non-physical performance (cognitive and mental symptoms) can prevent the progression of dementia, and can help to reverse the clinical neural function in order to improve the patient's situation. WSCMC observed through animal experimentation that the nerve cells that transform neural stem cells by medication not only can increase the amount of monoamine neural cells in the stem of the brain, but also can increase the number of choline basal ganglia neurons in the locus coeruleus. This can change the pathological situation of the cell membrane, cell cytoplasm and cell nucleus in the brain, in order to reduce and remove the accumulation of deformed protein.
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