Stefania Neculai-Cerebellar ataxia Myoclonic seizure-(Romania)

Patient name: Stefania Neculai
Gender: female
Age: 13 years old
Nationality: Romania
Disease diagnosis: 1.Cerebellar ataxia 2.Myoclonic seizure

Before treatment:
The patient had disturbance of balance, ataxia, intentional tremor of her extremities, unstable standing, inability to walk independently, and myoclonic seizures. At present, the patient was treated with levetiracetam tablets and had a generalized tonic clonic seizure every 2-3 months.

Physical examination:
Blood pressure 111/77mmHg, heart rate 88 beats / min. The nutrition of the patient was good, and no obvious abnormality was found in the general internal medical system examination.

Nervous system physical examination:
The patient was clear in mind and spoke well. She had good abilities of memory and calculation. Her cranial nerve examination showed no abnormality. The muscle strength of her limbs was grade 5 and her muscle tone was on the higher than normal. Her limb tendon reflexes were symmetrically active and her pathological signs were negative. Muscle bundle tremor could be seen in her limbs and trunk, and the tremor aggravated during fixed posture and exercise. Her Finger to nose movement, finger to finger movement and rotation movement were clumsy, and the calcaneus and tibia test could not be completed. It was difficult for her stable standing when her eyes were closed. She could not stand steadily and could not stand on one leg. Her deep and shallow feelings were normal and the meningeal irritation sign was negative.

Treatment process:
The patient’s diagnosis of admission was "1.Cerebellar ataxia 2.Myoclonic seizure". CAST therapy and neural stem cells + mesenchymal stem cells combined therapy were given to repair cerebral nerves, nutritive nerves, improve the internal environment, immunomodulation, rehabilitation training and others as comprehensive treatments.

After treatment:
After treatment, the motor state and balance function of the patient was significantly improved, the tremor of the extremities was significantly reduced, the coordination and stability of movement were improved, and the flexibility of limb movement was improved. The muscle tension of the extremities was generally normal. The finger to nose movement, opposite finger movement and rotation movement of her both hands were basically normal. The calcaneus, knee and tibia test could be completed. She could stand stably independently and stand on one leg for more than 3 seconds. Her walking ability was significantly improved. She could walk independently at a certain distance, and could complete continuous movement of turning in place.