Allen-Optic Atrophy-(Canada)

Name: Allen
Sex: Male
Country: Canada
Age: 4 years
Diagnosis: Cerebral Palsy, Optic Atrophy
Date of Admission: September 2nd, 2015
Treatment Hospital/period: Wu Medical Center/19 days

Before treatment:
The patient was born at mother's 29th week of pregnancy. His weight was 1.2Kg and his condition was normal after he was born. However, he had 2 operations due to intestinal obstruction and stayed in ICU for 10 months. He had to have gastrostomy to take nutrition. He had stool 3-4 times a day and seizures repeatedly. He suffered from retarded development of motion and intelligence and was diagnosed with ’Cerebral palsy and Optic atrophy’. He had therapies daily to improve his condition, but he was not able to pronounce, swallow and move voluntarily. Moreover, he had seizures dozens of times. 2 years and 1 year ago, he was admitted in our medical center and got improvement in his motion function and intelligence. After the treatment, he could pronounce ’a’ . He could take liquid food orally four times each day in which 3 times were liquid food 210mL and 1 time was soft food 150mL. He took medicine via gastrostomy. He could have some facial expressions to his parents. He required medicine to passed stools and defecated every other day. The frequency of seizures had been greatly reduced. He also gained weight and grew taller.

Admission PE:
Bp: 75/58mmHg; Pulse: 63/min. Br: 24/min. Ht: 86cm; Wt: 11.3kg. He was slow in body growth and not well-nourished. There was no yellow stain in the skin. There was scar on the forehead. The respiratory sounds in both lungs were clear, with no obvious moist or dry rales. The heart rate was 63/min, and the heartbeats were strong and regular. There was no obvious murmur in the valves. The abdomen was flat and there were scars of operations. He had gastrostomy on the abdomen and the abdominal percussion was normal. There were no abnormal masses in the abdomen and the liver and spleen were normal under palpate touch. The far-end muscle of left leg was contracted and malformed after operation. His left leg was shorter than right leg.

Nervous System Examination:
Patient was alert. He had speech dysfunction and could only pronounce ‘a’. He could not perform with examinations of memory, calculation and orientation. He had poor comprehensive ability. For some simple and yes-or-no question, he would smile as saying Yes while shut his month if he means No. He knew his parents through their voice and tone. The diameter of pupils was 3.5mm and both pupils had sensitive response to light stimuli. His eyeballs were sensitive to light. The forehead wrinkle pattern was symmetrical and the bilateral nasolabial groove was equal in depth. In supine position, his neck moved freely but his head had poor support when he sat. His head turned upward or downward easily. His muscle power of waist and back was weak. He could not turn his body himself when he was lying on the bed or keep a sit position. He could not perform with muscle strength or muscle tone examinations. The abdominal reflex was normal. The tendon reflex of arms was normal while that of legs was slightly active. Bilateral Achilles tendon reflex was normal and bilateral pathological reflex was negative. He could not cooperate with examinations of deep and shallow and coordination movement.

Treatment:
His diagnosis ‘Cerebral palsy; Optic atrophy' were confirmed. He was given four times’ injections of neural stem cells and mesenchymal stem cells to initiate his neural repair and regeneration, and also activate his own stem cells. He also received treatment to nourish nerves, improve circulation, and adjust immune system. This was accompanied with rehabilitation training. During the hospitalized period, he had fever, cough and phlegm. The temperature reached 37.7℃. The sputum culture was done and it was Escherichia coli. He was also given medicine of anti-inflammatory to get rid of sputum. His feeding posture was adjusted to avoid gastroesophageal reflux. His treatment was adjusted according to his condition and examination results.

Post-treatment:
After treatment, patient had no fever, cough or phlegm. The auscultation of lungs is normal. He was more alerted and the frequency of seizures has reduced conspicuously to 3-10 times a day. Now his eye can perceive the light because his eyes could follow the object in front of him. His swallowing ability gets better and the food-intake increases. He passes stool daily and does not need any medicine to help defecate. He has more vowels and facial expressions. He has more interaction with his family. His support to head is stronger and the strength of waist and back gets stronger. He is able to keep a sitting position partly and the grip strength and the controlling ability is getting stronger. The control of two legs grows better and he can raise them up from bed surface easily.