Amna Junaid-Retinopathy of prematurity stage V (ROP V)-(Pakistan)

Patient Name: Amna Junaid
Gender: Female
Age: 4 years old
Nationality: Pakistan
Diagnosis: Retinopathy of prematurity stage V (ROP V)

Before Treatment:
The child was admitted due to "lack of light perception in both eyes for over 4 years" diagnosed with "retinopathy of prematurity stage V".

Admission Examination:
The child's heart rate was 90 beats per minute, her respiratory rate was 23 breaths per minute, her height was 92 cm, and weight was 11.5 kg. General physical examination revealed sinus arrhythmia, but no other significant abnormalities were noted.

Neurological Examination:
The child was alert and her speech was generally normal. The right pupil measured 3 mm in diameter, while the left pupil was partially cloudy. There was no vision or light reflex in her both eyes. Fundoscopic examination revealed partial fibrous changes in the right retina with significant retinal detachment, presenting a pale yellow appearance and poor blood flow; the left retina appeared funnel-shaped with disorganized intraocular structures, retinal detachment, and poor perfusion. Eye movements in all directions were somewhat limited. Frontal wrinkles were symmetrical, and tongue protrusion was midline. Neck mobility was good. Muscle strength in all four limbs was generally rated at 5/5, and muscle tone was normal. Pathological signs were negative, and meningeal signs were also negative.

Treatment Process:
The child was clearly diagnosed with "retinopathy of prematurity stage V (ROP V)". She was given mesenchymal stem cells and neural stem cells to repair the retina and optic nerve, along with CAST treatment to nourish the retina and optic nerve, improve circulation, regulate immunity, and combined with comprehensive visual rehabilitation therapies.

After Treatment:
The child shows improvement in her visual function; light reflexes are present in both eyes, and she is able to perceive light and sometimes locate the light source, reaching out to touch it. She exhibites a withdrawal reflex to strong light. With the continuous repair of the retina by stem cell functions, she is expected to make further progress!