Mr. Saeed - Amyotrophic lateral sclerosis (Pakistan) Posted on March 1st, 2011

Name: Mr. Saeed  
Sex: Male
Country: Pakistan
Age: 45
Diagnosis: ALS (Amyotrophic lateral sclerosis)
Admission Date: 2011-01-10
Days Admitted to the Hospital: 33

Mr. Saeed developed spasms in his legs in 2007 with no obvious causes. He went to the hospital to have the spasms looked at, thinking the possible cause was a calcium deficiency. He received calcium supplements and vitamins for treatment but his condition didn't improve and became more severe. Both legs became increasingly weaker causing difficulty with walking. Mr. Saeed used to be able to walk a distance of 4-5 kilometers but eventually could only walk about 1-2 kilometers. Eventually the proximal lower limbs developed atrophy. He went to the local hospital and received an EMG, MRI, and a muscle biopsy specimen examination. He was diagnosed with motor neuron disease and took Riluzole for treatment. Four months later, he was taken off the medication because no improvements were seen. Mr. Saeed then went to Singapore for treatment, and received the same diagnosis of motor neuron disease. He received homeopathy in Pakistan. Along with the severe weakness in his legs, his arms also became increasingly weak with muscle atrophy in 2009. Things gradually progressed to the point where he could no longer walk, feed or dress himself or brush his teeth without assistance.

During the examination of the nervous system Mr.Saeed was alert and his mental faculties were good. His memory, calculation abilities and orientation were all normal. Both pupils were equal in size and round, the diameter was 3.0mm, and reacted normally to light stimuli. The movement of both eyeballs was flexible. There was mild atrophy in the lingualis. There was atrophy in the bilateral supraspinatus, infraspinous muscles, the interosseus muscles of both hands, the thenar muscles and muscles of the lower limbs' proximal end. The muscle strength of the upper right limb's proximal end was level 3+, and the distal end was level 4. The muscle strength of the upper left limb was level 4-. The grasping power of both hands was level 4. The muscle strength of both lower limbs was level 1. The muscle tone of all four limbs was normal. The tendon reflexes of both upper limbs were decreased. The tendon reflexes of both lower limbs were also decreased. The Hoffmann's sign was negative, the bilateral Babinski's sign was negative. There was normal deep and shallow sensation throughout the body.

Mr. Saeed could not successfully complete the finger-to-nose test. The rapid rotation test was performed in an unstable way. He couldn't complete the digital opposition test or the heel-knee-shin test. There were no signs of meningeal irritation.

Before we administered the stem cell treatment, Mr. Saeed received a complete examination and the diagnosis was clear. He was then given treatment in order to expand the blood vessels, nourish the neurons, promote nerve plerosis, diuresis, etc. This was combined with physical rehabilitation training. The laboratory examination showed elevated levels of aminotransferase and Uric Acid. He received treatment to bring down the aminotransferase and Uric Acid levels, and protection for the liver.

After the completion of the stem cell treatment, Mr. Saeed's condition gradually stabilized. The muscle strength of all four limbs has increased. The grasping power of the right hand has increased. The muscle strength of the lower limbs has increased, and both lower limbs can move back and forth on the flat surface of a bed for 5-7 times. The swelling in the back of the feet has almost completely disappeared. The aminotransferase and Uric Acid have been restored to normal levels.