Neil Antony Verner-Amyotrophic Lateral Sclerosis-(Britain)-Update on Mar. 22th, 2018

The second round of treatment:

Name: Neil Antony Verner
Sex: Male
Nationality: British
Age: 49Y
Diagnosis: 1. Amyotrophic Lateral Sclerosis (ALS) 2. Hypertension (1 degree) 
Date of Admission: Nov. 4th, 2017
Treatment hospital/period: Wu Medical Center/13 days

Before treatment:
The patient felt right leg weakness one and half years ago and it was hard for him to run. 15 months ago his arms became weak and he lost a lot of weight. He went to a local hospital and was diagnosed with ALS in October 2016.  He was prescribed Riluzole 50 mg. One month later his disease progressed, he had muscular fasciculation and right arm weakness. His balance function was bad 8 months ago, it was hard for him to go down stairs and he needed help to walk. He went to our hospital 6 months ago, his leg muscle power was increased and he walked better. For now his arms are weak, he needs help to go down stairs but he is able to take care of himself sometimes.
His spirit and appetite are good, his sleep has not been very good for a  year. His urination and defecation functions are basically normal. His swallowing function is good. He has hypertension and takes medicines to control it.

Admission PE:
Bp: 130/90mmHg, Hr: 65/min, breathing rate: 19/min, body temperature: 36.5 degrees. There is no injury or bleeding spots of his skin and mucosa, no blausucht. The chest development is normal, the respiratory sounds in both lungs were clear and there was no dry or moist rales. The heart beat is powerful with regular cardiac rhythm and no obvious murmur in the valves. The abdomen was flat and soft with no masses or tenderness. The liver and spleen were normal, shifting dullness is negative. The spinal column is normal and there was no edema in either leg.

Nervous System Examination:
Patient was alert and his mental status is good with clear speech. His memory, orientation and calculation abilities were normal . Both pupils were equal in size and round, diameter of 3 mm, react well to light and the eyeballs can move freely. There was no nystagmus. Bilateral forehead wrinkle and nasolabial fold are symmetrical and showing teeth is normal. His tongue is in middle with no tongue muscle atrophy and he can move his tongue freely. He can chew food and blow out the cheeks as normal. Soft palate of both sides is normal, the uvula is in normal position. Neck is soft and he can turn his neck freely. There is obvious muscle atrophy of the interosseous muscle of both hands, the thenar muscles, supraspinatus muscle and deltoid muscle. The  muscle volume of the four limbs is reduced. Left arm proximal abductor muscle power was 3 degrees, adductor and distal side abductor, adductor muscle power were 4- degrees, the right arm proximal side abductor muscle power was 3 degrees, adductor and distal side abductor, adductor muscle power were 4- degrees. Grip force of both hands were 4 degrees. The leg muscle power was 5- degrees. All 4 limbs muscle tone were normal. The tendon reflex of the arms was normal, of the legs was active. The bilateral ankle clonus were positive, Hoffmann sign of both sides were positive. The bilateral palm-jaw reflex were positive. The Babinski sign of both sides were negative. The finger to nose test of both sides were stable. The both hands fast alternate movement test results were basically normal. Finger opposite movement was normal. The heel-knee-tibia test was stable and accurate, the meningeal irritation sign is negative.

Treatment:
After the admission he received related examinations and received 3 neural stem cell injections and 3 mesenchymal stem cell injections to repair his damaged nerves, replace dead nerves with new injected stem cells, nourish nerves, regulate his immune system and improve blood circulation. This was done with rehabilitation training.     

Post-treatment:
After 13 days treatment the patient's muscle fasciculation reduced and the sport endurance is better. The arm muscle power increased 10-20%, his limbs are more flexible and his grip is improved. The muscle power of the legs also increased and he walks better.

The first round of treatment:

Name: Neil Antony Verner
Sex: Male
Nationality: British
Age: 49Y
Diagnosis: Amyotrophic Lateral Sclerosis (ALS) 
Date of Admission: March 19th, 2017
Treatment hospital/period: Wu Medical Center/14 days

Before treatment:
Patient had no obvious indication of the onset of right lower limb weakness 1 year ago but he was unable to run well 9 months ago. The upper limbs then appeared weaker and his weight dropped significantly. He went to hospital and was diagnosed with "amyotrophic lateral sclerosis" in October 2016. He was given riluzole 50mg twice daily but after taking the pills he felt limb stiffness and difficulty in movement so he stopped taking it. He had muscle tremor, right arm strength decreased significantly, his balance ability was bad and within three months it was difficult for him to go down stairs without assistance. At present the right arm strength of the patient is significantly reduced and the strength of the other limbs are reduced. He has poor balance, needs to be assisted going down stairs but he could take care of himself mostly. He came to our hospital for further treatment.
Patient has good spirit and appetite, he has had shallow sleep patterns for nearly 4 months. It is easy for him to be woken up and he doesn’t use any sleeping pills. He has normal urination and defecation ability. He could swallow well and he has lost 10 kgs already.

Admission PE:
Bp: 126/89mmHg, Hr: 65/min, breathing rate: 19/min, body temperature: 36 degrees. Nutrition status is good with normal physical development. There is no injury or bleeding spots of his skin and mucosa, no blausucht. The chest develop is normal, the respiratory sounds in both lungs were clear, there was no dry or moist rales. The heart beat is powerful with regular cardiac rhythm and with no obvious murmur in the valves. The abdomen was flat and soft, with no masses or tenderness. The liver and spleen were normal, shifting dullness is negative. The spinal column is normal, there was no edema in either leg.

Nervous System Examination:
Patient was alert and his mental status is good with clear speech. His memory, orientation and calculation ability were normal. Both pupils were equal in size and round, diameter of 3mm, react well to light, eyeballs can move freely. No nystagmus. Bilateral forehead wrinkle and nasolabial fold are symmetrical, showing of teeth is normal. His tongue is in the middle and there is no tongue muscle atrophy, he can move his tongue freely. He can chew food and blow out the cheek as normal. Soft palate lift of both sides is normal, the uvula is in normal position. Neck is soft and he can turn his neck freely. There is obvious muscle atrophy of the interosseous muscle of both hands and the thenar muscles. The muscle volume is not very high. The muscle power of the left arm is 4 degrees, right arm is 4- degrees, the grip force of both hands is 5- degrees, muscle power of the legs is 5- degrees. Muscle tone of all 4 limbs is normal. The tendon reflex of the arms is normal, of the legs is active. The bilateral ankle clonus were positive; the Hoffman sign of both sides were positive; the Palm-jerk reflex of both sides were positive; Babinski sign of both sides were negative. Finger to nose test was stable and the patient can perform the fast alternate movement as normal. Finger opposite movement is normal. The bilateral Heel-knee-tibia test is stable, the meningeal irritation sign is negative.

Treatment:
After the admission, he received related examinations and diagnosed with ALS. He received 3 neural stem cell injections and 3 mesenchymal stem cell injections to repair his damaged nerves, replace dead nerves with new injected stem cells, nourish nerves, regulate his immune system and improve blood circulation. This was done with rehabilitation training.     

Post-treatment:
After 14 days treatment he has better spirit and energy, muscle fasciculation is reduced and physical endurance is better. The muscle power of both arms is increased with the left arm increased to level 4+ and the right side increased to level 4. He can now walk longer distances.

E-mails:

Date:2017-9-10

Dear Dr. Wang

All my functions including height and weight remain constant,

Blood pressure is normal, occasionally slightly high but within acceptable tolerance.

Recently I had blood tests and sent them to Evelyn, please review, all were good but my CK was even higher, why would that be?

My General strength is up, BUT MY SHOULDERS ARE GETTING SIGNIFICANTLY WEAKER, please advise what I can do immediately.

I do my exercise daily exactly as prescribed.

My oxygen saturation is between 98-99%

Please see my photo

Kind regards,

Neil