Adam-Cerebral palsy-(Argentina)-Update on Nov.29th, 2016

The second round of treatment:

Name: Adam Gabriel Gonealez
Sex: Male  
Nationality: Argentine
Age: 11 years old  
Diagnosis: Cerebral Palsy
Admission Date: May 2nd, 2016
Treatment hospital/ period: Wu Medical Center/ 22 days

Before treatment:
The patient was suffered from asphyxia then years ago when he was born with two weeks cord around the neck. He appeared apnoeic after birth. After the secure, he had the normal vital signs. After 24 house of his birth, he had first time epilepsy, and after 48 hours, he had second seizure of epilepsy. Then he was given the treatment to take medicine of Barbitone. The patient was discovered with abnormal movement function after 16 days since he was born and was diagnosed with Cerebral Palsy. And after that, the development of his movement function and recognition function was slower than other children in same age. At his 3 months, he was stopped to take Barbitone due to his epilepsy was stopped. Because he has the paroxysmal  panic, he was given the medicine baclofen for three years, but he did not get effect. Three years later, he was attacked by epilepsy frequently and he had the interval grand seizure, so he was given the medicine with diazepam, but his epilepsy was not improved. Since five years later, he was given Clobazam to control his epilepsy and the seizure of his epilepsy was reduced gradually and he did not have grand seizure of epilepsy. Three years ago, he was attacked by grand seizure of epilepsy once every two months and he was given additional medicine with levetiracetam. Two years ago, he came to our hospital for nerve repairing treatment. After treatment, the seizure degree of his epilepsy was obviously reduced, the movement of his limbs was more flexibly compared to his before status, he can turn himself over, and his muscle tension is reduced. Half a year ago, he had an operation on his left hip joint, after such operation, his movement function was limited and in order to have further improvement, he came to our hospital for treatment. His spirit is weak since he had this disease, his swallowing function is better changed, his sleep is good, his defecation is regular with three to five times per day, his urination is relied on the baby diaper and its quantity and color is basically normal.

Admission PE:
Bp: 118/74mmHg. Hr: 96/min. Body temperature: 36.4 degree. Height: 133cms, weight: 23kgs. He had mild thoracic valgus. The respiratory sounds in both lungs were clear, with no dry or moist rales. His heart sound was strong, the cardiac rate was normal, there was no obvious murmur in the valves. The abdomen was soft and flat. The liver and spleen were normal. Both of his lower limbs were not deopsical.

Nervous System Examination:
Adam Gabriel Gonealez was alert but his spirit was bad, he was not able to speak, he had lags in response. He didn’t cooperate with the memory, orientation ability or calculation examinations. Both pupils were equal in size and round and both pupils were sensitive to light stimulus. The eyes were not in the right position, he was able to move his eyes very well. His tongue was centered in his mouth, his uvula was in the right position. His neck was soft, it was difficult for him to raise his head, the muscle tension of his neck was lower than normal, he was able to move his head. He didn’t cooperate with the muscle examinations of limbs, either. He was not able to control his limbs’ movements. The muscle of his trunk was weak, so he was not able to sit up or walk, but he was able to turn over to left and right. The muscle tension of four limbs was a little higher than normal. Both of his waists bend to ulnar side and palmar side. Both of his arms supinated. Both his hips and knees leaned to right a little and were in flexed position. Bilateral abdominal reflexes were abnormal. Bilateral radial periosteal reflex, biceps reflex and triceps reflex were weaker. Bilateral patella tendon reflex and ankle reflex were normal. Bilateral ankle clonus, sucking reflex and palm-jaw reflex were negative. Left Hoffmann sign was positive, right Hoffmann sign was negative, left Babinski sign was negative, right Babinski sign was positive. He didn’t cooperate with other examinations.    

Treatment:
After admission, Adam was diagnosed with Cerebral Palsy, he received four times Mesenchymal stem cells injection and four times Neural stem cells injection, so as to initiate the repairing of nerve and regeneration of nerve, activate his in-vivo stem cells, initiate the growth of nerve, improve the blood circulations, nourish neurons, regulate the immunity and control epileptic attack. He also had physical rehabilitation.

Post Treatment:
His spirit is better changed, his reaction speed is faster, he can communicate with his family member, he can make pronunciation for some words. He got more power of his trunk, he got the ability to sit up in semi-reclining position, he is more flexibly to turn himself over, and his power in lower limbs is increased, his movement function is improved, the movement space of his bone joint is enlarged and his muscle tension is better changed. He did not got the seizure of epilepsy and his eating status is better.

The first round of treatment:

Name:Adam Gabriel Gonealez                 
Sex: Male
Country: Argentina
Age: 8
Diagnoses: Cerebral palsy
Date: March 31, 2014
Days Admitted to Hospital: 29 days

Before treatment:
The patient suffered from suffocation at birth. He had a cord around his neck two weeks. He had no breath after birth. After he was rescued, the patient had vital signs were recorded. 24 hours later, the patient suffered first time epileptic seizure. 48 hours later, the patient suffered the second time epileptic seizure. He took phenobarbital for therapy. 16 days later, the patient was found suffering from motor function abnormality. He was diagnosed with cerebral palsy. Then the patient suffered from obvious delay in movement and cognitive function. He suffered from delay compared to normal baby. He stopped taking phenobarbital when he was 3 months for there was no epileptic seizure. He suffered from paroxysmal terrified and took baclofen for 6 months. This had no effect. 6 years ago, the patient suffered frequently epilepsy and suffered from general grand mal discontinuously. He took diazepam, but the epileptic seizure did not reduce. He took Clobazam to control the epilepsy 4 years ago. The epileptic seizure was reduced gradually. About 6 months ago, the patient suffered from epileptic seizure every 2 months. He took levetiracetam, but there was still some remnant of the epileptic seizure.

From the onset of disease, the patient had weak spirit. He had swallowing difficulty, had semiliquid and feeds 8 times each day. The sleep was still good. He suffered constipation and defecates every 3-5 days. He used paper diaper for urine and the urine color was almost normal. The patient cannot speak. He also had dyskinesia and cognitive disorder.

Admission PE:
Bp: 88/46mmHg; Hr: 73/min. Temperature: 36.6 degrees. Height: 120cm, Weight: 18.5Kg. The thorax had mild extroversion. The respiratory sounds in both lungs were clear, with no dry or moist rales. The cardiac rhythm was regular, with no murmur in the valves. The abdomen was stressed, with masses like stool mass. The liver and spleen were not palpable under the ribs. There was no swelling in both lower limbs.

Nervous System Examination:
Adam Gabriel Gonealez was alert, but he had poor spirit. He had apraxia of speech. He couldn't communicate with others. He had slow response. He had  paroxysmal acoustic sensitivity epilepsy. He couldn't cooperate with the examination of memory, orientation or calculation. He suffered from paroxysmal acoustic sensitivity epilepsy. Both pupils were equal in size and round. Both pupils reacted normally to light stimulus. The eye position was abnormal. The movement of both eyeballs was not sufficient. The tongue was in the center of the oral cavity.  The uvula was in the center of oral cavity.  The neck was soft and the patient had difficulty with raising his head. The muscle tone of neck decreased.  The muscle tone of four limbs was slightly higher than normal. He was always bending upper limbs (wrists and other joints) and knees. His feet presented plantar flexion. He had no control of his four limbs. The muscle strength of his trunk was weak. He couldn't turn over, sit-up or walk. Bilateral abdominal reflexes were not elicited. Bilateral radioperiosteal reflex, biceps reflex, patellar tendon reflex and ankle reflex were active. Bilateral ankle clonus was negative. The sucking reflex was positive. The left palm jaw reflex was negative. The right reflex was positive. Bilateral Hoffmann sign was negative. He couldn’t cooperate with the examination of other physical examination.

Treatment:
After the admission, Adam Gabriel Gonealez received the relevant examinations and was diagnosed with Cerebral palsy. He received treatment for nerve regeneration and to activate stem cells in the body. He received treatment to improve the blood circulation in order to increase the blood supply to the damaged nerves and also to nourish the neurons. He also received treatment to control epilepsy and neural activation.  This was combined with physical rehabilitation training.

Post-treatment:
Adam Gabriel Gonealez's has better spirit and emotion. He has more appetite, eat more and eat quicker than before. The epileptic seizure has disappeared. The constipation has been alleviated together with defecation for every 2 days. His pronunciation is clearer than before. The muscle strength in his trunk has increased. He can sit-up from half lying position.

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