Dilan Lorenzo-Cerebral Palsy-(Uruguay)-Posted on Jan.14th, 2016

Name: Dilan Lorenzo
Sex: Male
Nationality: Uruguayan
Age: 2 years and 10 months
Diagnosis: 1. Cerebral Palsy; 2. Optic Nerve Retardation; 3. Sinus Arrhythmia (suspicious for Sick sinus syndrome(SSS))
Date of Admission: November 19, 2015
Treatment hospital/period: Wu Medical Center/25 days

Before treatment:
The patient was born by natural labour at 40 weeks of gestation. During the pregnancy, he was found to have umbilical cord around his neck. He appeared apnoeic after birth. He was sent to the intensive care unit. He had seizures during hospitalization, and he was given antiepileptic drugs. He was discharged from the hospital one month later. Before he was 1-year-old, anti-epileptic drugs were gradually reduced and finally stopped. After he was discharged, he experienced no epileptic attack again. He was found to have abnormal vision, retarded development in motion, spirit and intelligence by his families. He was taken to hospital and was diagnosed as cerebral palsy, optic nerve retardation. There was no obvious improvement with rehabilitation training. Up to now, he had suffered from retarded development in motion, spirit and intelligence obviously. He could not speak; he expressed his anger by rapid breath. Environmental stimulus, makes him curled his arms and straightened legs. He was able to grasp things. When he was in prone position, his arms could support his upper part of body for 2-3 seconds. He could not turn over, crawl, or keep a sitting or standing position. His heels were unable to be grounded when he stood with assistance. His parents want a better life, so they brought him to our centre.

The patient's spirit was good; he slept well. He had semi-liquid diet. His urination was normal. He defecated once per 2-3 days, with drug’s (Lactulose) help.

Admission PE:
Tp: 36.3℃; Br: 24-55/min; Bp: 80/40mmHg. Peripheral blood oxygen saturation: 92-96%. Height: 75cm; Weight: 10Kg. He was slow in growth. He was well-nourished. There were no yellow stains on skin. His lips had no cyanosis. The pharyngeal had no congestion. The thorax had malformation. The respiratory sound in lungs was clear without moist or dry rales. There was sonorous rale when he breathed rapidly. Hr: 55-160/min. The heart sound was good and the rhythm was no well-ordered and there was no obvious murmur in the valves. The abdomen was flat. The liver and spleens were normal. He had scoliosis. The legs had no edema. Electrocardiogram showed: short PR interval period, sinus arrhythmia.

Nervous System Examination:
Dilan was conscious and in a good spirit. He could not cooperate with memory, calculation and orientation test. He could not communicate with others. He expresses anger by rapid breath. The diameter of both pupils was 3.0mms, and both pupils were equal in size and round. The pupils moved in full range. The left side was sensitive to light stimulus and the right side was dull. He could not cooperate with cranial nerve examination. He was able to grasp things and the muscle strength of grip was at level 4. He could not cooperate with muscle strength of limbs and muscle tone examination.   When he was in prone position, his arms could support his upper part of body for 2-3 seconds. He could not turn over, crawl, or keep a sitting or standing position. His heels were unable to be grounded when he stood with assistance. The biceps reflex, radial periosteal reflex and patellar tendon reflex were normal. Bilateral Babinski sign were positive. He could not cooperate with sensation and coordination tests. The meningeal irritation sign was negative.

Treatment:
The diagnoses of 1. Cerebral palsy; 2. Optic Nerve Retardation; 3. Sinus arrhythmia (suspicious for Sick sinus syndrome(SSS)) were confirmed. We had a comprehensive treatment including 4 times neural stem cells and mesenchymal stem cells implantation to activate the stem cells in the body and start nerve repair and nerve regeneration; nerve nourishment; circulation improvement; protecting heart; and immune regulation therapy. This was companied with rehabilitation for motion and speech.

Post-treatment:
After 25 days of treatment, patient’s heart and lung function have strengthened; heart rate 78-120/min, breath 26-48/min. Finger-tip oxyhemoglobin saturation 97-99%. Nerve function has improved. The pupils were more sensitive to light stimulus especially his left eye. He can turn over to one side. He bends his legs more frequently and flexibly evidently. His muscle tension has been alleviated. He could maintain sitting position with other’s help. There is decrease stress and increase expression. His face appeared pleased expression.
 

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