Rolandas Sestokas-Multiple sclerosis-(Lithuania)

Patient name: Rolandas Sestokas
Gender: Male
Age: 45 years old
Nationality: Lithuania
Diagnosis: Multiple sclerosis

Condition on admission:
The patient was admitted to hospital for "multiple sclerosis" due to "progressive limb weakness and numbness for more than 20 years, aggravated with balance disorder for 3 years".

Admission for physical examination:
His heart rate was 67 beats per minute, breathing 18 beats per minute, and blood pressure 128/88mmHg. He is 183cm in height and 80kg in weight. He is well-developed and well-nourished; his lungs have clear breathing sounds; his heart sounds are strong and rhythmic; his abdomen is soft.

Nervous system physical examination:
The patient has clear mind, normal spirit, clear speech, normal calculation, memory and orientation, bilateral pupil same size, about 3mm, sensitive light reflex, no defect in visual field and no nystagmus. His forehead lines were symmetrical, his bilateral nasolabial grooves were equal in depth, his tongue was in the middle, and there was no obvious atrophy of the tongue muscles. His neck moved freely, the muscle tension of his upper limbs was basically normal, the muscle tension of his lower limbs was high, and his legs twitched involuntarily. His left upper limb muscle strength and grip strength was grade 2+, his right upper limb muscle strength and grip strength was grade 3-, and his lower limb muscle strength was grade 2. His abdominal wall reflex was not elicited. He had a decreased tendon reflex in both upper limbs and an active knee tendon reflex in both lower limbs. His bilateral Hoffmann sign was negative and his bilateral Babinski sign was positive. The deep and shallow sensation of his lower limbs decreased; the finger-nose test of his hands was not stable, the rotation test of his hands was clumsy, and the completion of the finger-to-finger test of his hands was not good (his left hand could barely touch the second finger, and his right hand could slowly reach the 2.3.4 finger). His lower limbs calcaneus knee tibia test could not be completed due to muscle strength. His meningeal irritation sign was negative.

Treatment process:
The patient was diagnosed as multiple sclerosis on admission. He was given mesenchymal stem cells to regulate immunity, neural stem cells to repair the injury of nerve axons and myelin sheath, assisted with drug CAST treatment, and combined with rehabilitation therapy.

After treatment:
The limb motor function of the patient was significantly improved, his involuntary leg twitch was significantly reduced, his limb numbness was significantly relieved, his upper limb muscle strength was significantly enhanced, his grip strength was significantly improved, and the fine movement of his fingers was enhanced. He regained the ability to carry a cup of water and operate a wheelchair independently. The strength of his torso, waist and back increased, and he regained the ability to turn over independently. The muscle strength of his lower limbs increased, his tension significantly improved, and he could complete the preliminary functions of standing and walking with primary assistance. His left upper limb muscle strength and grip strength is grade 3+, his right upper limb muscle strength and grip strength is grade 4, and his lower limb muscle strength is grade 3-. The muscle tension of his limbs is basically normal; his abdominal wall reflex can be drawn out, and his limb tendon reflex is basically normal. The deep and shallow sensation of his upper limbs tends to be normal, his deep and shallow sensory disorders of both lower limbs recovered significantly, the stability of his hands finger nose test increased, his hand rotation test flexibility increased, and the completion of his two hands finger test improved (the left hand can touch the second and third fingers, the right hand can complete all finger pointing movements). His energy, physical stamina and sports endurance have increased significantly.