Jane Smith-1.Multiple system atrophy 2.Hypertension grade 3-(Canada)

Patient name: Jane Smith
Gender: Female
Age: 67 years old
Nationality: Canada
Disease diagnosis: 1.Multiple system atrophy 2.Hypertension grade 3

Before treatment:
The patient’s main reason was "dizziness, unstable walking for more than 5 years, aggravation with drinking water cough for more than 1 year" and she was admitted as "multi-system atrophy". Her main symptoms: dizziness, unstable walking, easy to pour backward, accompanied by fatigue, unclear speech, low and weak pronunciation, slow speech speed, and gradual aggravation of the disease. In the past year, the symptoms of her walking instability gradually aggravated and fell frequently, resulting in one time arm fracture and one time lumbar fracture. And when drinking water she choked, accompanied by poetic language, no nausea and vomiting. In the local hospital she underwent neurological examination, laboratory examination, nuclear magnetic resonance examination-level gene monitoring, etc., and she was clearly diagnosed as "multi-system atrophy". She has a history of hypertension for more than 20 years.

Admission for physical examination:
The patient’s blood pressure 140/80mmHg. Her development is normal and the nutrition is moderate. No wet rales was heard in her both lungs. Arrhythmia, strong heart sound, A2 > P2, the second heart sound enhanced. Her abdomen is soft and the liver and spleen are not enlarged.

Nervous system physical examination:
The patient’s mind is clear, the spirit is ok. Her articulation was not clear, her pronunciation was weak, her pronunciation was low and weak, and her speech speed was slow, like chanting poetry. The ability of her calculation and orientation were normal, and the responses of her memory and understanding were normal. Her bilateral pupil was equal in size, about 2mm in diameter, sensitive to light reflex, inferior to the normal horizontal movement of both eyes, exposed white area 2-3mm, limited supravision, and small nystagmus in horizontal and vertical directions. The hearing of both ears is normal. The forehead pattern is symmetrical, the bilateral nasolabial groove is equal to depth, the quarrel of mouth is not biased, the tongue is in the center, the tongue muscles on both sides are slightly atrophied, and the uvula is in the middle. There was no hyperemia in pharynx, no obvious enlargement of tonsil, dull pharyngeal reflex, free movement of her neck, grade 4 muscle strength of limbs, normal muscle tension of limbs, active tendon reflex and negative pathological reflex. The surface and deep feelings of her whole body are basically normal, and the bilateral rotation test, finger test and finger nose test she completed slowly. The completion of the calcaneus, knee and tibia test is acceptable. She could not stand alone, shaking, easy to pour back, eyes closed difficult to stand sign and open eyes difficult to stand sigh were all positive. Her meningeal irritation sign was negative.

Treatment process:
The diagnosis of the patient’s admission was "1, multiple system atrophy 2, hypertension grade 3". CAST therapy and neural stem cells + mesenchymal stem cells were given for her to repair cerebral nerves, nourish nerves, improve the internal environment, immune regulation and rehabilitation training.

After treatment:
Her dizziness was significantly relieved, her articulation improved, her voice was louder, her speech speed increased, her language fluency improved, her binocular movement was not obviously limited, and the nystagmus was significantly reduced. The motor function of her limbs was improved, the strength of her limbs was enhanced, the flexibility of her limb movement was improved, the muscle strength of her limbs was grade 4 +, and her feeling of fatigue disappeared. The balance function has been significantly improved, including standing alone with eyes open for more than 2 minutes, eyes closed for 45 seconds, and each leg for 5 seconds. Her energy, physical fitness and sports endurance were significantly improved.