Huu Long Nguyen-Parkinson's disease(Vietnam)

The fourth round of treatment:

Name: Huu Long Nguyen
Sex: Male
Nationality: Vietnamese
Age: 55Y
Diagnosis: 1. Parkinson Disease 2. Borderline hypertension 3. HLP(hyperlipidaemia)
Discharge Date: 2018/10/23

Before treatment:
The patient felt stiffness in his limbs without any reason 9 years ago, he moved slowly, his right hand shook when he wrote and he wrote letters  smaller and smaller when he continually wrote. His condition became worse and worse and his life and work were affected so he went to hospital 1 year later and was diagnosed with Parkinson's disease. He took medicines and his condition became better but it still progressed slowly. His medicines were adjusted 6 years ago, he began to take Sinemet, but the side effect was bad and he had amaurosis so he took less doses of it. His work and life were affected obviously and so he went to our hospital in May 2013, February 2015, September 2016 and February 2018 to do stem cell treatments. After the treatments  his condition became better, he could work and had a normal life. One month ago he began to take madopar instead of sinemet and his condition became worse, especially from 8:00am to 11:00 a.m. .
His diet is good, he does not sleep well, his urination function is not good and he has dry stools.

Admission PE:
Bp 126/87mmHg, Hr: 67/min, breathing rate: 17/min, body temperature: 36 degrees. He has basically a normal gait but without arm swing. Nutrition status was good but he tended to feel tired. There was no injury or bleeding spots of his skin and mucosa, no blausucht, no throat congestion and his tonsils were not swollen. The respiratory sounds in both lungs were clear and there were no dry or moist rales. The heart beat was powerful with regular cardiac rhythm and no obvious murmur in the valves. The abdomen was flat and soft with a little bit of tension and with no masses or tenderness. The liver and spleen were normal and there was no edema of the legs.

Nervous System Examination:
Patient was alert and had slight slurred speech. His memory was decreased, the comprehension and calculation abilities were normal. He had reduced facial expression, both pupils were equal in size and round, diameter of 3.0 mm and the reaction to light was sensitive. The eyeballs could move freely with no nystagmus. The bilateral forehead wrinkle and nasolabial fold were symmetrical, he could make his tongue extend out normally, there was tongue muscle tremor and the tongue muscle could move flexibly. The soft palate could lift powerfully, the uvula was normal, he felt rigid to turn his neck to the left side and the right side was normal. The 4 limbs movement was slower  than normal with no obvious body tremor. Left side body muscle power was 5- degrees, right side was 4+ degrees, he could roll over in bed but his body was unsteady when he turned over but he could  walk or get up slowly. He had difficulty to start to walk but a normal walking speed. His 4 limbs muscle tone were normal. Bilateral biceps reflex, triceps reflex and radial periosteal reflex were normal. Bilateral Achilles tendon reflex and patellar tendon reflex were lower than normal, bilateral Hoffmann sign and Rossilimo sign were negative. Sucking reflex and palm-jaw reflex were negative, bilateral Babinski sign were negative, sensory system examination was normal. He could perform the finger opposite movement and the fast alternate movement was clumsy. The finger to nose test was flexible, heel-knee-tibia test was stable, the Romberg sign was a mild positive. He tended to fall forward when walking, the meningeal irritation sign was negative.

Treatment:
After the admission he received 3 nerve regeneration treatments (neural stem cells and mesenchymal stem cells) to repair his damaged nerves, replace dead nerves, nourish nerves, regulate his immune system and improve blood circulation. This was combined  with rehabilitation training.     

Post-treatment:
After 11 days treatment his tongue muscle tremor reduced, he spoke better, the slow movement and rigidity alleviated, he moved faster, he could walk and go up stairs easier, he could run better and his trunk balance was much better. He could turn over and get up from bed well and his onset problem was gone.

The third round of treatment:

Diagnoses: Parkinson's disease
Discharge Date:
2018/02/20

Before treatment:
The patient felt stiffness in his limbs without any reason 10 years ago. He moved slowly, his right hand shook when he wrote, he wrote letters smaller and  smaller when he continually wrote. His condition became worse and worse, his life and work were affected. He went to a hospital 1 year later and was diagnosed with Parkinson's disease. He took medicines and his condition became better but his disease progressed slowly. His medicines were adjusted 6 years ago, he began to take Sinemet but the side effect was bad. He had amaurosis, so he took less doses of it and his work and life were affected obviously. He went to our hospital 3 times and after treatment his condition became better, he could work and had a normal life.
His diet and sleep are good, his urination and defecation functions are good. He put on 5 kgs six years ago after our treatment.

Admission PE:
Bp: 136/89mmHg; Hr: 75/min. RP:19/min. His body shape was good and his gait was normal without arms swinging. It was easy for him to get tired and his nutrition was normal. There was no ecchymosis, petechia or yellow stains on his skin. There was no congestion in the pharyngeal area and the tonsils were not enlarged. The respiration in both lungs was clear with no dry or moist rales. Through auscultation the heart sound was strong with no murmur in each valve. The abdomen was flat and soft, his abdominal muscle was a little tense but without tenderness or rebound tenderness. There were no masses. The liver and spleen were not touched under the rib. There was no swelling in either leg.

Nervous System Examination:
Huu Long Nguyen was alert and his speech was a little slurred but his speech speed was passable. His memory, orientation and calculation abilities were normal. His facial expression was not as rich as normal. Both pupils were equal in size and round, the diameter was about 3.0mm. Both pupils were sensitive to light stimulus and both eyeballs could move freely to each side. He had no nystagmus. The forehead wrinkle pattern was symmetrical and bilateral nasolabial grooves was symmetrical. The tongue was in the center of oral cavity and there was no tremor, he had strong muscle power to lift his soft palate and the uvula had not deflected. He could turn his head freely though it looked rigid when turning left. The movement of the four limbs was a little slow but without obvious tremor. The muscle power of the left side was at level 5-, right side was at level 4+. Sometimes he turned over, stood up and walked slowly. He had no obvious starting difficulty to walk, his walking speed was passable but he was a little unstable to turn around. The muscle tension of the four limbs was normal. Bilateral biceps, triceps brachii and radial periosteal reflex were normal. Both sides patella tendon reflex and achilles reflex were lower. Bilateral Hoffmann sign, Rossilomo sign, bilateral sucking reflex, bilateral palm jaw reflex and bilateral Babinski sign were negative. Bilateral deep, shallow and fine sensation was normal. Right side finger to finger movement and rapid alternating movement was a little clumsy, while he did it flexibly on the left side. Bilateral finger to nose movement was flexible. He did the heel-knee-tibia test in a stable manner. The Romberg sign was weakly positive. He always bent forward when walking. Meningeal irritation sign was negative.

Treatment:
The patient received 2 times nerve regeneration treatment(neural stem cells and mesenchymal stem cells) to repair damaged nerves, replace dead nerves, active stem cells in his body, Anti-Parkinson, to provide nourishment to the neurons, expand the blood vessels in order to improve the blood supply to the brain and stabilize organ function. This was combined with physical rehabilitation training.          

Post-treatment:
After 7 days of treatment he was in a stable condition, his spirit was good and he could move freely. He spoke more clearly, his expression was higher, his neck became free to move, his limbs were flexible and he moved faster. He could take good care of himself.

The second round of treatment:
Diagnoses: Parkinson's disease
Date of Admission: Sept. 25th, 2016

Before treatment:
Huu Long Nguyen felt stiffness in limbs without any reason, he moved slowly, his right hand shook when he wrote, he wrote letters more and more smaller when he continually wrote. His condition became worse and worse, his life and work were affected. He went to hospital 1 year later and diagnosed with Parkinson's disease, he took medicines, his condition became better but his disease progressed slowly. His medicines were adjust 4years ago, he began to take Sinemet, but the side effect was bad, he had amaurosis, so he took less dose of it, his work and life were affected obviously. He went to our hospital in May 2013 and February 2015 to do stem cells treatment, and after treatment, his condition became better, he could work and had a normal. At present, his limbs are slowly to move, he speaks slowly, his right shoulder, neck and right upper limb are stiffness. He wants a better life so he comes to our hospital again.
His diet and sleep are good, his urination and defecation are good. He put up 5 kgs 4 years ago after our treatment.

Admission PE:
Bp: 120/80mmHg; Hr: 69/min. RP:18/min. His body shape was good, his movement of swing arms were not very flexible. He was easy to get tired and his nutrition was normal. There was no ecchymosis, petechia or yellow stains on skin. There was no congestion in pharyngeal area. The tonsil was not enlarged. The respiration in both lungs was clear, no dry or moist rales. Through auscultation, the heart sound was strong, with no murmur in each valve. The abdomen was flat and soft, his abdominal muscle was a little tension without tenderness or rebound tenderness. There was no mass. The liver and spleen was not touched under the rib. There was no swelling in both lower limbs.

Nervous System Examination:
Huu Long Nguyen was alert and his speech was not clear but fast. His memory, orientation and calculation were normal. His facial expression was not much. Both pupils were equal in size and round, the diameter was about 3.0mm. Both pupil was sensitive to light stimulus. Both eyeballs could move freely to each side. He had no nystagmus. The forehead wrinkle pattern was symmetrical and bilateral nasolabial grooves was symmetrical. The tongue was in the center of oral cavity. There was no tremor in tongue. He had strong muscle to lift his soft palate. The uvula had not deflected. He could turn head effective,. The movement four limbs were a little slowly without tremor. The muscle power of left side was at level 5, right side was at level 5-. Sometimes he turned over, got up and walked slowly. He had no obvious difficult to start to walk, the speed was good. The muscle tension of four limbs was normal. Bilateral biceps, triceps brachii and radial periosteal reflex were normal. Both side patella tendon reflex and achilles reflex were lower. Bilateral Hoffmann sign, Rossilomo sign, bilateral sucking reflex, bilateral palm jaw reflex, bilateral Babinski sign were negative. The depth sensation and epicritic sensibility were normal. He couldn’t do alternate motion and finger-to-finger test in right side very well, but the left side was normal. Both side finger-to-nose texts were good. He did the heel-knee-tibia test in a stable manner. The Romberg sign was weakly positive. He always bent forward when he walking. Meningeal irritation sign was negative.

Treatment:
Huu Long Nguyen was diagnosed with Parkinson’s disease. He received 3 neural stem cell injections and 3 mesenchymal stem cell injections to repair damaged nerves, replace dead nerves with new injected stem cells, active stem cells in his body, Anti-Parkinson, to provide nourishment to the neurons, expand the blood vessels in order to improve the blood supply to the brain and stabilize organ function. This was combined with physical rehabilitation training.          

Post-treatment:
After 10 days of treatment, his was in stable condition, his spirit and mood was good, he could speak fluently, he could move freely. He could take good care of himself. His right shoulder, neck and upper limb were more flexible.

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