Charles Stanberry -Parkinson's disease, tardive dyskinesia, dementia -(Costa Rican)

Patient Name: Charles Stanberry
Gender: Male
Age: 79 years old
Nationality: Costa Rican
Diagnosis: Parkinson's disease, tardive dyskinesia, dementia

Before Treatment:
The patient's main symptoms included bradykinesia, balance disorders, progressive impairment of limb movements, and repetitive actions. He also experienced cognitive impairments, poor comprehension, significant decline in memory and calculation abilities, slow thinking, difficulty in verbal expression, decreased swallowing function, occasional choking, and sometimes drooling. He had difficulty controlling urination and defecation (used adult diapers) and experienced occasional constipation (used fiber laxatives to assist with bowel movements). He was currently taking medications including Quetiapine, Citalopram, Trazodone, Gabapentin, and Perphenazine, and received botulinum toxin injections every 2-3 months to manage tardive dyskinesia. He denied any other chronic diseases or history of infectious diseases.

Physical Examination Upon Admission:
The patient's blood pressure was 122/72 mmHg, heart rate was 44 beats per minute, and respiratory rate was 18 breaths per minute. He was 175 cm tall and weighed 77 kg. He presented with a forward-leaning posture. His skin showed no signs of jaundice, and his lips exhibited no cyanosis. Both lungs had clear breath sounds, with no dry or wet rales heard. Heart sounds were weak with a slow rhythm of 44 beats per minute, and there were no murmurs. The abdomen was soft, with no tenderness or rebound tenderness; the liver and spleen were not enlarged. There was no significant edema observed in both lower extremities.

Neurological Examination:
The patient was alert but appears anxious. His speech was unclear, comprehension was poor, and he showed delayed responses, making it difficult for him to answer questions. There was a significant decline in his memory and calculation abilities, as he was unable to perform simple addition and subtraction within ten. Both pupils were 2 mm in diameter with a normal light response. Ocular movement was limited, and there were no signs of nystagmus; his facial expression was rigid and apathetic. Nasolabial folds were symmetrical, and tongue protrusion was slow and centered. He exhibited repetitive chewing movements. There was a swallowing dysfunction, as he tended to choke easily while drinking. Muscle strength in the limbs was grade 4, with increased muscle tone noted, particularly in the upper limbs. All limb movements were slow. He demonstrated repetitive actions such as sitting down and standing up. Tendon reflexes in the limbs were diminished. Pathological reflexes were negative. He was uncooperative during deep and superficial sensation examinations. Coordination tests were not feasible due to his lack of cooperation. He exhibited an unstable gait characteristic of Parkinson's disease and required assistance for walking. Signs of meningeal irritation were negative.

Treatment Process:
Upon admission, the patient was clearly diagnosed with "Parkinson's disease, tardive dyskinesia, and dementia." He was treated with a combination of neural stem cells, mesenchymal stem cells, and CAST therapy to repair brain nerve lesions, nourish brain neurons, improve circulation, regulate immunity, and stabilize the function of various organs. This was supplemented with comprehensive rehabilitation therapy.

Post-Treatment:
The patient's mental and cognitive functions have significantly improved compared to his condition upon admission. He is now able to engage in conversations with family members, using a larger vocabulary and constructing more complex sentences. His responses to external stimuli are quicker and more responsive than before. There is notable enhancement in his calculation and memory abilities. The typical posture associated with Parkinson's disease has improved markedly. His facial rigidity has decreased, allowing for a more expressive face, and he can now smile. Repetitive actions, such as chewing, have reduced in frequency. Muscle stiffness and slowness in his limbs have significantly alleviated, leading to increased flexibility in his movements. He has progressed from struggling to use a spoon to now being able to eat with chopsticks and even using a spoon to cut cake. Stiffness in his lower limbs is gradually easing, with improved mobility and a reduction in gait rigidity. His muscle strength has increased from grade 4 to grade 5. Cardiopulmonary function has also improved, with his heart rate stabilizing between 50-65 beats per minute. He expressed great joy by climbing the Great Wall of China.